Neuroimmunologie und Rheumatologie: Schnittmengen und Differenzialdiagnosen

Trebst, C. und Kuempfel, T. (2018): Neuroimmunologie und Rheumatologie: Schnittmengen und Differenzialdiagnosen. In: Nervenarzt, Bd. 89, Nr. 10: S. 1095-1105

Abstract

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are chronic inflammatory diseases of the central nervous system (CNS). They may cause inflammation in the brain, spinal cord and optic nerve. Both conditions must be differentiated from CNS manifestations of other systemic autoimmune diseases such as systemic lupus erythematosus (SLE), Sjogren's syndrome, autoinflammtory diseases and sarcoidosis, since amongst others myelitis and optic nerve inflammation may also occur in these conditions. Nevertheless, coexistence of MS or NMOSD with rheumatic disorders such as SLE or Sjogren's syndrome has also been reported especially in NMOSD. Since the therapeutic approach is different it is important to determine aclear diagnosis. In addition some drugs used in rheumatic disease such as anti-tumor necrosis factor biologics may induce inflammatory disease of the CNS and should be avoided in MS. An interdisciplinary approach between neuroimmunology and rheumatology is important for optimal care and treatment in such patients.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0028-2804
• Sprache: Deutsch