A genome-wide association study of early gamma-band response in a schizophrenia case-control sample

Konte, Bettina; Leicht, Gregor; Giegling, Ina; Pogarell, Oliver; Karch, Susanne; Hartmann, Annette M.; Friedl, Marion; Hegerl, Ulrich; Rujescu, Dan and Mulert, Christoph (2018): A genome-wide association study of early gamma-band response in a schizophrenia case-control sample. In: World Journal of Biological Psychiatry, Vol. 19, No. 8: pp. 602-609

Abstract

Objectives: Disturbances in the gamma-frequency band of electroencephalography (EEG) measures are among the most consistently observed intermediate phenotypes in schizophrenia. We assessed whether genetic variations are associated with gamma-band activity. Methods: We performed a genome-wide association analysis of the early auditory evoked gamma-band response in schizophrenia affected subjects and healthy control individuals (in total N = 315). Results: No marker surpassed the threshold for genome-wide significant association. Several of the markers that were closest to significance mapped to genes involved in neuronal development and the Neuregulin-ErbB signalling network, such as NRG2 and KALRN. Using a gene-set enrichment analysis, we found suggestive evidence for association with genes involved in EEG abnormality (P = .048). Conclusions: We identified no marker genome-wide significantly associating with gamma response;independent replication of the gene-set analysis result and larger sample sizes will be required to provide leads to cellular pathways involved in gamma-band activity.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1562-2975
• Language: English