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Yang, Bo-Yi; Bloom, Michael S.; Markevych, Iana; Qian, Zhengmin (Min); Vaughn, Michael G.; Cummings-Vaughn, Lenise A.; Li, Shanshan; Chen, Gongbo; Bowatte, Gayan; Perret, Jennifer L.; Dharmage, Shyamali C.; Heinrich, Joachim; Yim, Steve Hung-Lam; Lin, Shao; Tian, Linwei; Yang, Mo; Liu, Kang-Kang; Zeng, Xiao-Wen; Hu, Li-Wen; Guo, Yuming; Dong, Guang-Hui (2018): Exposure to ambient air pollution and blood lipids in adults: The 33 Communities Chinese Health Study. In: Environment International, Vol. 119: pp. 485-492
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Abstract

Background: Little information exists on the lipidemic effects of air pollution, particularly in developing countries. We aimed to investigate the associations of long-term exposure to ambient air pollutants with lipid levels and dyslipidemias in China. Methods: In 2009, a total of 15,477 participants aged 18-74 years were recruited from the 33 Communities Chinese Health Study conducted in three Northeastern China cities. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured in participants' blood specimens. Three year (2006-08) average air pollution concentrations were assessed using data from 33 communities (particles with diameters <= 1.0 mu m (PM1) and <= 2.5 mu m (PM2.5) were predicted using a spatial statistical model) or 11 air monitoring stations (particles with diameters <= 10 mu m (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O-3)). Associations were evaluated by two-level logistic and generalized linear regression models. Results: We detected many significant associations between exposure to air pollutants (especially for PM1 and PM2.5) and blood lipid levels. Most of the associations suggested deleterious effects on blood lipid markers (e.g., a 10 mu g/m(3) increase in PM1 was associated with 1.6% (95% confidence interval (CI): 1.1, 2.0), 2.9% (95% CI: - 3.3, 9.3), and 3.2% (95% CI: 2.6, 3.9) higher levels of TC, TG, and LDL-C, respectively, but 1.4% (95% CI: - 1.8, -0.9) lower HDL-C levels), although beneficial associations were found for O-3. In analysis with dyslipidemias, all the observed associations suggested deleterious lipidemic effects of air pollutants, and no significant beneficial association was observed for O-3. Stratified analyses showed that the associations were stronger in overweight or obese participants;sex and age modified the associations, but the pattern of effects was mixed. Conclusions: Long-term ambient air pollution was associated with both altered lipid profiles and dyslipidemias, especially among overweight or obese participants.