Synthesis of next generation dual-responsive cross-linked nanoparticles and their application to anti-cancer drug delivery

SchwarzenBöck, Christina; Nelson, Peter J.; Huss, Ralf and Rieger, Bernhard (2018): Synthesis of next generation dual-responsive cross-linked nanoparticles and their application to anti-cancer drug delivery. In: Nanoscale, Vol. 10, No. 34: pp. 16062-16068

Abstract

Rare earth metal-mediated group transfer polymerisation enables the synthesis of previously inaccessible block copolymers of 2-vinylpyridine, diethyl vinylphosphonate and the new diallyl vinylphosphonate monomer. This precision polymerisation and the selective cross-linking of allyl side groups via thiol-ene click chemistry leads to the formation of well-defined dual-responsive nanoparticles. We demonstrate that these next generation nanocarriers are pH- and temperature-responsive and are capable of efficiently delivering doxorubicin into the nucleus of cancer cells. High anti-cancer activity could be demonstrated via cytotoxicity tests on breast cancer (MCF-7) and cervical cancer (HeLa) cells. These results validate this modular synthesis route as an ideal platform for the development of sophisticated nanocarriers for future drug delivery applications.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 2040-3364
• Language: English