Tauopathien. Vom Molekül zur Therapie

Kovacs, G. G.; Respondek, G.; Eimeren, T. van; Hoeller, E.; Levin, J.; Müller, U.; Schwarz, S.; Roesler, T. W.; Schweyer, K. und Höglinger, G. U. (2018): Tauopathien. Vom Molekül zur Therapie. In: Nervenarzt, Bd. 89, Nr. 10: S. 1083-1094

Abstract

Background. The microtubule-associated tau protein is the defining denominator of agroup of neurodegenerative diseases termed tauopathies. Objective. Provide atimely state of the art review on recent scientific advances in the field of tauopathies. Material and methods. Systematic review of the literature from the past 10years. Results. Tau proteins are increasingly being recognized as ahighly variable protein, underlying and defining aspectrum of molecularly defined diseases, with aclinical spectrum ranging from dementia to hypokinetic movement disorders. Genetic variation at the tau locus can trigger disease or modify disease risk. Tau protein alterations can damage nerve cells and propagate pathologies through the brain. Thus, tau proteins may serve both as aserological and imaging biomarker. Tau proteins also provide abroad spectrum of rational therapeutic interventions to prevent disease progression. This knowledge has led to modern clinical trials. Conclusion. The field of tauopathies is in a state of dynamic and rapid progress, requiring close interdisciplinary collaboration.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0028-2804
• Sprache: Deutsch