Abstract
Background. Pathophysiological links between inflammation, obesity, and adipokines can be used for the treatment of metabolic dysregulation. Aims. To examine the influence of duodenal-jejunal omega switch surgery in combination with different diet patterns on plasma concentrations of fatty acid-binding protein 4 (FABP4), C-reactive protein (CRP), leptin, and chemerin. Methods. After 8 weeks on a high-fat diet (HF) or control diet (CD), rats underwent surgery. Duodenal-jejunal omega switch (DJOS) with an exclusion of one-third of intestinal length and SHAM surgery were performed. For the next 8 weeks, 50% of DJOS/SHAM animals were kept on the same diet as before (HF/DJOS/HF, HF/SHAM/HF, CD/DJOS/CD, and CD/SHAM/CD), and 50% had a changed diet (HF/DJOS/CD, HF/SHAM/CD, CD/DJOS/HF, and CD/SHAM/HF). FABP4, CRP, leptin, and chemerin were assessed using ELISA kits. Results. FABP4: significant differences between DJOS and SHAM were observed in animals maintained on CD/CD;CRP: varied between DJOS and SHAM groups maintained on HF/HF, CD/CD, and CD/HF;leptin and chemerin levels: DJOS lowered leptin and chemerin plasma levels versus SHAM, while HF/HF, CD/HF, and HF/CD significantly increased leptin and chemerin plasma levels when compared to CD/CD. Conclusions: The beneficial effect of DJOS surgery is stronger than proinflammatory conditions caused by an HF obesogenic diet.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| URN: | urn:nbn:de:bvb:19-epub-65607-7 |
| ISSN: | 1942-0900 |
| Sprache: | Englisch |
| Dokumenten ID: | 65607 |
| Datum der Veröffentlichung auf Open Access LMU: | 19. Jul. 2019, 12:18 |
| Letzte Änderungen: | 04. Nov. 2020, 13:46 |
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