EEG coherence in a mental arithmetic task performance in first episode schizophrenia and schizoaffective disorder

Zaytseva, Yuliya; Garakh, Zhanna; Novototsky-Vlasov, Vladimir; Gurovich, Isaac Ya.; Shmukler, Alexander; Papaefstathiou, Anna; Horacek, Jiri; Spaniel, Filip und Strelets, Valeria B. (2018): EEG coherence in a mental arithmetic task performance in first episode schizophrenia and schizoaffective disorder. In: Clinical Neurophysiology, Bd. 129, Nr. 11: S. 2315-2324

Abstract

Objectives: To evaluate the coherence values of the cortical bands in patients with first episode schizophrenia and schizoaffective disorder during the performance of a mental arithmetic task. Method: We analysed EEG coherence in the resting state and subsequently while counting down from 200 in steps of 7 in 32 first episode schizophrenia patients (SZ), 32 patients with first episode schizoaffective disorder (SA) and 40 healthy controls (HC). Results: Task performance in HC is characterised by decreased coherence in the alpha bands and increased coherence in the beta 2 and gamma bands in frontal sites. In SZ, coherence decreases in the alpha band, whereas in SA it substantially increases in the alpha, betal, beta 2 and gamma bands. Conclusions: Despite no differences in performance on a behavioural level, SA patients demonstrate a paradoxical increase in both low and fast frequency bands during the performance of a mental arithmetic task, while, patients with SZ show a decreased coherence in the alpha band, presumably alluding to the excessive excitatory (in SA) and inhibitory (in SZ) mechanisms in cognitive processing. Significance: The current study provides evidence for the distinction of neurophysiological mechanisms of cognitive processing between SZ and SA.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1388-2457
• Sprache: Englisch