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Walliser, Isabelle; Göbel, Thomas W. (2018): Chicken IL-17A is expressed in alpha beta and gamma delta T cell subsets and binds to a receptor present on macrophages, and T cells. In: Developmental and Comparative Immunology, Vol. 81: pp. 44-53
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IL-17A as important cytokine in host defense has been analysed intensively and various homologous have been identified. To further gain insight into the functional properties of chicken (gg) IL-17A its expression profile was analysed by intracellular cytokine staining. In splenocytes and peripheral blood mononuclear cells gg IL-17A was detected in subsets of CD4(+) T cells and gamma delta T cells. In contrast the gg IL-17A producing populations in intestinal intraepithelial lymphocytes were characterized as either CD3(+)CD25(+) cells or gamma delta T cells. Furthermore, using FLAG tagged gg IL-17A, binding to its receptor was demonstrated on the macrophage cell line HD11. In peripheral blood IL-17A binding activity was found on zeta beta and gamma delta T cell subsets, monocytes and a distinct population of CD25(high) cells. Treatment of HD11 cells with gg IL-17A induced IL-6 mRNA expression and nitric oxide production. These results demonstrate the presence of alpha beta T helper(17) cell subset and IL-17 producing gamma delta T cells in the chicken.