Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascin-positive/-negative Head and Neck Squamous Cell Carcinoma

Zivicova, Veronika; Gal, Peter; Mifkova, Alzbeta; Novak, Stepan; Kaltner, Herbert; Kolar, Michal; Strnad, Hynek; Sachova, Jana; Hradilova, Miluse; Chovanec, Martin; Gabius, Hans-Joachim; Smetana, Karel Jr. und Fik, Zdenek (2018): Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascin-positive/-negative Head and Neck Squamous Cell Carcinoma. In: Anticancer Research, Bd. 38, Nr. 3: S. 1279-1290

Abstract

Background/Aim: Having previously initiated genome-wide expression profiling in head and neck squamous cell carcinoma (HNSCC) for regions of the tumor, the margin of surgical resecate (MSR) and normal mucosa (NM), we here proceed with respective analysis of cases after stratification according to the expression status of tenascin (Ten). Materials and Methods: Tissue specimens of each anatomical site were analyzed by immunofluorescent detection of Ten, fibronectin (Fn) and galectin-1 (Gal-1) as well as by microarrays.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Tiermedizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0250-7005
• Sprache: Englisch