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Datz, Stefan; Illes, Bernhard; Gößl, Dorothée; Schirnding, Constantin von; Engelke, Hanna; Bein, Thomas (2018): Biocompatible crosslinked beta-cyclodextrin nanoparticles as multifunctional carriers for cellular delivery. In: Nanoscale, Vol. 10, No. 34: pp. 16284-16292
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Nanoparticle-based biomedicine has received enormous attention for theranostic applications, as these systems are expected to overcome several drawbacks of conventional therapy. Herein, effective and controlled drug delivery systems with on-demand release abilities and biocompatible properties are used as a versatile and powerful class of nanocarriers. We report the synthesis of a novel biocompatible and multifunctional material, entirely consisting of covalently crosslinked organic molecules. Specifically, -cyclodextrin (CD) precursors were crosslinked with rigid organic linker molecules to obtain small (approximate to 150 nm), thermally stable and highly water-dispersible nanoparticles with an accessible pore system containing -CD rings. The nanoparticles can be covalently labeled with dye molecules to allow effective tracking in in vitro cell experiments. Rapid sugar-mediated cell-uptake kinetics were observed with HeLa cells, revealing exceptional particle uptake within only 30 minutes. Additionally, the particles could be loaded with different cargo molecules showing pH-responsive release behavior. Successful nuclei staining with Hoechst 33342 dye and effective cell killing with doxorubicin cargo molecules were demonstrated in live-cell experiments, respectively. This novel nanocarrier concept provides a promising platform for the development of controllable and highly biocompatible theranostic systems.