Biomimetic Synthesis of (+)-Aspergillin PZ

Reyes, Julius R.; Winter, Nils; Spessert, Lukas und Trauner, Dirk (2018): Biomimetic Synthesis of (+)-Aspergillin PZ. In: Angewandte Chemie-International Edition, Bd. 57, Nr. 47: S. 15587-15591

Abstract

The cytochalasans are a large family of polyketide natural products with potent bioactivities. Amongst them, the aspochalasins show particularly intricate and fascinating structures. To gain insight into their structural diversity and innate reactivity, we have developed a rapid synthesis of aspochalasin D, the central member of the family. It proceeded in 13 steps starting from divinyl carbinol and utilized a high pressure Diels-Alder reaction that features high regio- and stereoselectivity. So far, our work has culminated in a biomimetic synthesis of aspergillin PZ, an intricate pentacyclic aspochalasan.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1433-7851
• Sprache: Englisch