Cobalt-Catalyzed Diastereoselective Cross-Couplings between Alkynylzinc Pivalates and Functionalized Cyclic Iodides or Bromides

Thomas, Lucie; Lutter, Ferdinand H.; Hofmayer, Maximilian S.; Karaghiosoff, Konstantin und Knochel, Paul (2018): Cobalt-Catalyzed Diastereoselective Cross-Couplings between Alkynylzinc Pivalates and Functionalized Cyclic Iodides or Bromides. In: Organic Letters, Bd. 20, Nr. 8: S. 2441-2444

Abstract

Various 1,2-, 1,3-, and 1,4-substituted cyclic iodides or bromides undergo highly diastereoselective cross-couplings (diastereoselectivity (dr) up to 99:1) with a range of alkynylzinc pivalates, using CoCl2 (20 mol %) and trans-N,N,N',N'-tetramethylcyclohexane-1,2-diamine as a catalytic system.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1523-7060
• Sprache: Englisch