Copper complexes of new thiosemicarbazone ligands: Synthesis, structural studies and antimicrobial activity

Ibrahim, Ahmed B. M.; Farh, Micheal K. und Mayer, Peter (2018): Copper complexes of new thiosemicarbazone ligands: Synthesis, structural studies and antimicrobial activity. In: Inorganic Chemistry Communications, Bd. 94: S. 127-132

Abstract

Two thiosemicarbazone (TSC) ligands {HL1 = 4-(2,5-dimethoxypheny1)-1-((pyridin-2-yl)methylene)thiosemicarbazide and HL2 = 4-(3-nitropheny1)-1-((pyridin-2-yemethylene)thiosemicarbazidel were prepared for the first time and characterized based on elemental analyses and spectroscopic (IF. and electronic) measurements. Complexation reactions between the ligands and CuCl2 resulted in the formation of two complexes {[CuCI(L-1)](2) 1 and [CuCl(L-2)](2) 2}. The crystal structure of 1 has been investigated by single crystal X-ray studies and was proved to be dimeric consisting of square pyramidal geometries around the Cu atoms as each Cu atom binds two bridging chlorine atoms and three atoms (two N, one S) from the TSC ligand. Ligands were tested against microbial strains and displayed no activity. Upon coordination, the activity was enhanced and, in some cases, was found comparable to that exhibited by the clotrimazole antifungal and chloramphenicol antibacterial standards.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1387-7003
• Sprache: Englisch