Zincation and Magnesiation of Functionalized Silylated Cyanohydrins Using TMP-Bases

Castello-Mico, Alicia und Knochel, Paul (2018): Zincation and Magnesiation of Functionalized Silylated Cyanohydrins Using TMP-Bases. In: Synthesis-Stuttgart, Bd. 50, Nr. 1: S. 155-169

Abstract

Polyfunctional silylated cyanohydrins are readily magnesiated or zincated with TMPMgClLiCl or TMP2 Zn2MgCl(2)2LiCl leading to the corresponding metallated derivatives. These Mg- or Zn-derivatives react with various electrophiles such as benzylic bromides, allylic bromides, acid chlorides, aldehydes, NCCO2Et, or MeSO2SMe. Subsequently, TBAF-deprotection provides the corresponding keto or 1,2-diketo derivatives.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0039-7881
• Sprache: Englisch