Logo Logo
Help
Contact
Switch Language to German
Castello-Mico, Alicia; Knochel, Paul (2018): Zincation and Magnesiation of Functionalized Silylated Cyanohydrins Using TMP-Bases. In: Synthesis-Stuttgart, Vol. 50, No. 1: pp. 155-169
Full text not available from 'Open Access LMU'.

Abstract

Polyfunctional silylated cyanohydrins are readily magnesiated or zincated with TMPMgClLiCl or TMP2 Zn2MgCl(2)2LiCl leading to the corresponding metallated derivatives. These Mg- or Zn-derivatives react with various electrophiles such as benzylic bromides, allylic bromides, acid chlorides, aldehydes, NCCO2Et, or MeSO2SMe. Subsequently, TBAF-deprotection provides the corresponding keto or 1,2-diketo derivatives.