Castello-Mico, Alicia and Knochel, Paul
(2018):
Zincation and Magnesiation of Functionalized Silylated Cyanohydrins Using TMP-Bases.
In: Synthesis-Stuttgart, Vol. 50, No. 1: pp. 155-169
Abstract
Polyfunctional silylated cyanohydrins are readily magnesiated or zincated with TMPMgClLiCl or TMP2 Zn2MgCl(2)2LiCl leading to the corresponding metallated derivatives. These Mg- or Zn-derivatives react with various electrophiles such as benzylic bromides, allylic bromides, acid chlorides, aldehydes, NCCO2Et, or MeSO2SMe. Subsequently, TBAF-deprotection provides the corresponding keto or 1,2-diketo derivatives.
| Item Type: | Journal article |
|---|---|
| Faculties: | Chemistry and Pharmacy > Department of Chemistry |
| Subjects: | 500 Science > 540 Chemistry |
| ISSN: | 0039-7881 |
| Language: | English |
| Item ID: | 67518 |
| Date Deposited: | 19. Jul 2019, 12:22 |
| Last Modified: | 04. Nov 2020, 13:49 |
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