Einer, Claudia; Hohenester, Simon; Wimmer, Ralf; Wottke, Lena; Artmann, Renate; Schulz, Sabine; Gosmann, Christian; Simmons, Alisha; Leitzinger, Christin; Eberhagen, Carola; Borchard, Sabine; Schmitt, Sabine; Hauck, Stefanie M.; Toerne, Christine von; Jastroch, Martin; Walheim, Ellen; Rust, Christian; Gerbes, Alexander L.; Popper, Bastian; Mayr, Doris; Schnurr, Max; Vollmar, Angelika M.; Denk, Gerald; Zischka, Hans (2018): Mitochondrial adaptation in steatotic mice. In: Mitochondrion, Vol. 40: pp. 1-12 |
Abstract
Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium. These changes preceded hepatocyte damage and were not associated with enhanced ROS production. Thus, WD-mitochondria do not promote steatohepatitis per se, but demonstrate bioenergetic deficits and increased sensitivity to stress signals.
Item Type: | Journal article |
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Faculties: | Medicine |
Research Centers: | Center for Integrated Protein Science Munich (CIPSM) |
Subjects: | 500 Science > 540 Chemistry 600 Technology > 610 Medicine and health |
ISSN: | 1567-7249 |
Language: | English |
ID Code: | 68166 |
Deposited On: | 19. Jul 2019 12:24 |
Last Modified: | 04. Nov 2020 13:50 |
- BASE
- Einer, Claudia
- Hohenester, Simon
- Wimmer, Ralf
- Wottke, Lena
- Artmann, Renate
- Schulz, Sabine
- Gosmann, Christian
- Simmons, Alisha
- Leitzinger, Christin
- Eberhagen, Carola
- Borchard, Sabine
- Schmitt, Sabine
- Hauck, Stefanie M.
- Toerne, Christine von
- Jastroch, Martin
- Walheim, Ellen
- Rust, Christian
- Gerbes, Alexander L.
- Popper, Bastian
- Mayr, Doris
- Schnurr, Max
- Vollmar, Angelika M.
- Denk, Gerald
- Zischka, Hans
- Google Scholar
- Einer, Claudia
- Hohenester, Simon
- Wimmer, Ralf
- Wottke, Lena
- Artmann, Renate
- Schulz, Sabine
- Gosmann, Christian
- Simmons, Alisha
- Leitzinger, Christin
- Eberhagen, Carola
- Borchard, Sabine
- Schmitt, Sabine
- Hauck, Stefanie M.
- Toerne, Christine von
- Jastroch, Martin
- Walheim, Ellen
- Rust, Christian
- Gerbes, Alexander L.
- Popper, Bastian
- Mayr, Doris
- Schnurr, Max
- Vollmar, Angelika M.
- Denk, Gerald
- Zischka, Hans