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Einer, Claudia; Hohenester, Simon; Wimmer, Ralf; Wottke, Lena; Artmann, Renate; Schulz, Sabine; Gosmann, Christian; Simmons, Alisha; Leitzinger, Christin; Eberhagen, Carola; Borchard, Sabine; Schmitt, Sabine; Hauck, Stefanie M.; Toerne, Christine von; Jastroch, Martin; Walheim, Ellen; Rust, Christian; Gerbes, Alexander L.; Popper, Bastian; Mayr, Doris; Schnurr, Max; Vollmar, Angelika M.; Denk, Gerald and Zischka, Hans (2018): Mitochondrial adaptation in steatotic mice. In: Mitochondrion, Vol. 40: pp. 1-12

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Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium. These changes preceded hepatocyte damage and were not associated with enhanced ROS production. Thus, WD-mitochondria do not promote steatohepatitis per se, but demonstrate bioenergetic deficits and increased sensitivity to stress signals.

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