Communication between neocortex and hippocampus during sleep in rodents

Sirota, Anton ; Csicsvari, Jozsef; Buhl, Derek und Buzsáki, György (2003): Communication between neocortex and hippocampus during sleep in rodents. In: Proceedings of the National Academy of Sciences of the United States of America : PNAS, Bd. 100, Nr. 4: S. 2065-2069

Abstract

Both neocortical and hippocampal networks organize the firing patterns of their neurons by prominent oscillations during sleep, but the functional role of these rhythms is not well understood. Here, we show a robust correlation of neuronal discharges between the somatosensory cortex and hippocampus on both slow and fine time scales in the mouse and rat. Neuronal bursts in deep cortical layers, associated with sleep spindles and delta waves/slow rhythm, effectively triggered hippocampal discharges related to fast (ripple) oscillations. We hypothesize that oscillation-mediated temporal links coordinate specific information transfer between neocortical and hippocampal cell assemblies. Such a neocortical-hippocampal interplay may be important for memory consolidation.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Lehrstuhl für Kognition und Neuronale Plastizität
• Themengebiete: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0027-8424
• Sprache: Englisch