Challenges in Clinical Trial Design for T Cell‐Based Cancer Immunotherapy

Kruger, Stephan F.; Cadilha, Bruno L.; Bergwelt‐Baildon, Michael von; Endres, Stefan und Kobold, Sebastian (2020): Challenges in Clinical Trial Design for T Cell‐Based Cancer Immunotherapy. In: Clinical Pharmacology & Therapeutics, Bd. 107, Nr. 1: S. 47-49

Abstract

Chimeric antigen receptor T cells can induce impressive response rates in patients with refractory B cell malignancies. Adoptive transfer of tumor infiltrating lymphocytes or T cell receptor‐engineered T cells are other promising treatment modalities currently in clinical development. Requirements for clinical trial design for T cell‐based cancer immunotherapy significantly differ from established criteria for small‐molecule or antibody‐based anticancer drugs. Here, we highlight important differences regarding preclinical development, trial design, and reporting of clinical trials.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0009-9236
• Sprache: Englisch