Abstract
This study investigates the application of broadband capacitive micromachined ultrasonic transducers (CMUT) to ionoacoustics (i.e., the thermoacoustic emissions induced by the energy deposition of ion beam) over a wide frequency range from hundreds of kHz to a few MHz. A water tank was irradiated by a 20 MeV pulsed proton beam. The frequency and amplitude of the ionoacoustic waves were modulated by adding material before to penetrate into the water tank to change the beam energy and its spatial dimensions. The measurements were performed with a 12 MHz CMUT prototype and compared to ones obtained from commercial 3.5 MHz piezoeletric transducer as well as to in silico studies employing the k-Wave Matlab toolbox in combination with FLUKA Monte Carlo simulations to derive the dose (i.e., energy deposition per mass) and initial pressure distribution. Comparison of the experimental and in silico results show that the CMUT bandwidth is wide enough to measure the signal without any degradation or attenuation of the frequency content in the investigated frequency range, thus ensuring accurate reconstruction of the dose distribution and potential bi-modality system for the co-registration of ionoacoustic and ultrasound imaging.
Dokumententyp: | Konferenzbeitrag (Paper) |
---|---|
EU Funded Grant Agreement Number: | 725539 |
EU-Projekte: | Horizon 2020 > ERC Grants > ERC Consolidator Grant > ERC Grant 725539: SIRMIO - Small Animal Ion Irradiator for Research in Molecular Image-Guided Radio-Oncology |
Publikationsform: | Submitted Version |
Keywords: | CMUT; ionoacoustics; proton range verification |
Fakultät: | Physik |
Themengebiete: | 500 Naturwissenschaften und Mathematik > 530 Physik
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
URN: | urn:nbn:de:bvb:19-epub-70677-4 |
Sprache: | Englisch |
Dokumenten ID: | 70677 |
Datum der Veröffentlichung auf Open Access LMU: | 27. Feb. 2020, 11:09 |
Letzte Änderungen: | 04. Nov. 2020, 13:52 |
Literaturliste: | [1] K. C. Jones, C. M. Seghal, and S. Avery, “How proton pulse characteristics influence protoacoustic determination of proton-beam range: 2213, 2016. [2] S. Kellnberger, W. Assmann, S. Lehrack, S. Reinhardt, P. Thirolf, D. Queirós, G. Sergiadis, G. Dollinger, K. Parodi, and V. Ntziachristos, “Ionoacoustic tomography of the proton bragg peak in combination with ultrasound and optoacoustic imaging,” Scientific reports, vol. 6, p. 29305, 2016. [3] M. Vallet, F. Varray, J. Boutet, J.-M. Dinten, G. Caliano, A. S. Savoia, and D. Vray, “Quantitative comparison of pzt and cmut probes for photoacoustic imaging: Experimental validation,” Photoacoustics, vol. 8, pp. 48-58, 2017. [4] W. Assmann, S. Kellnberger, S. Reinhardt, S. Lehrack, A. Edlich, P. Thirolf, M. Moser, G. Dollinger, M. Omar, V. Ntziachristos et al., “Ionoacoustic characterization of the proton bragg peak with submillimeter accuracy,” Medical physics, vol. 42, no. 2, pp. 567-574, 2015. [5] G. Caliano, A. S. Savoia, C. Longo, A. Caronti, M. Pappalardo, A. Iula, and S. Rothmann, “cmut sensor for applications as a wide-band acoustic receiver in the mhz range,” in 2010 IEEE International Ultrasonics Symposium. IEEE, 2010, pp. 1869-1872. [6] B. E. Treeby and B. T. Cox, “k-wave: Matlab toolbox for the simulation and reconstruction of photoacoustic wave fields,” Journal of biomedical optics, vol. 15, no. 2, p. 021314, 2010. [7] M. Sautto, A. S. Savoia, F. Quaglia, G. Caliano, and A. Mazzanti, “A comparative analysis of cmut receiving architectures for the design optimization of integrated transceiver front ends,” IEEE transactions on ultrasonics, ferroelectrics, and frequency control, vol. 64, no. 5, pp. 826- 838, 2017. |