Breathing coordinates limbic network dynamics underlying memory consolidation

Karalis, Nikolaos und Sirota, Anton (2018): Breathing coordinates limbic network dynamics underlying memory consolidation. bioRxiv,

Abstract

The coordinated activity between remote brain regions underlies cognition and memory function. Althoughneuronal oscillations have been proposed as a mechanistic substrate for the coordination of information trans-fer and memory consolidation during sleep, little is known about the mechanisms that support the widespreadsynchronization of brain regions and the relationship of neuronal dynamics with other bodily rhythms, such asbreathing. Here we address this question using large-scale recordings from a number of structures, includingthe medial prefrontal cortex, hippocampus, thalamus, amygdala and nucleus accumbens in mice. We identifya dual mechanism of respiratory entrainment, in the form of an intracerebral corollary discharge that actsjointly with an olfactory reafference to coordinate limbic network dynamics, such as hippocampal ripplesand cortical UP and DOWN states, involved in memory consolidation. These results highlight breathing, aperennial rhythmic input to the brain, as an oscillatory scaffold for the functional coordination of the limbiccircuit, enabling the segregation and integration of information flow across neuronal network

• Dokumententyp: Paper
• Fakultät: Medizin > Lehrstuhl für Kognition und Neuronale Plastizität
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch