Impaired biotin status in anticonvulsant therapy

Krause, Klaus-Henning; Berlit, Peter and Bonjour, Jean-Pierre (1982): Impaired biotin status in anticonvulsant therapy. In: Annals of Neurology, Vol. 12, No. 5: pp. 485-486

Abstract

In 264 epileptics undergoing long-term therapy with anticonvulsants, significantly reduced plasma biotin levels were found compared with a normal control group: 74% of the epileptics had biotin levels for those treated with sodium valproate were higher than for those treated with phenytion, primidone, or carbamazepine. The observed reduction in biotin levels might be a factor influencing the efficacy of these three antionvulsants.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health