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Krause, Klaus-Henning; Berlit, Peter; Bonjour, Jean-Pierre (1982): Impaired biotin status in anticonvulsant therapy. In: Annals of Neurology, Vol. 12, Nr. 5: S. 485-486




In 264 epileptics undergoing long-term therapy with anticonvulsants, significantly reduced plasma biotin levels were found compared with a normal control group: 74% of the epileptics had biotin levels for those treated with sodium valproate were higher than for those treated with phenytion, primidone, or carbamazepine. The observed reduction in biotin levels might be a factor influencing the efficacy of these three antionvulsants.