Krause, Klaus-Henning; Berlit, Peter; Bonjour, Jean-Pierre
Impaired biotin status in anticonvulsant therapy.
In: Annals of Neurology, Vol. 12, No. 5: pp. 485-486
In 264 epileptics undergoing long-term therapy with anticonvulsants, significantly reduced plasma biotin levels were found compared with a normal control group: 74% of the epileptics had biotin levels for those treated with sodium valproate were higher than for those treated with phenytion, primidone, or carbamazepine. The observed reduction in biotin levels might be a factor influencing the efficacy of these three antionvulsants.