Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation

Klein, Ludger ; Robey, Ellen A. und Hsieh, Chyi-Song (Januar 2019): Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation. In: Nature Reviews Immunology, Bd. 19: S. 7-18

Abstract

The diversion of MHC class II-restricted thymocytes into the regulatory T (Treg) cell lineage, similarly to clonal deletion, is driven by intrathymic encounter of agonist self-antigens. Somewhat paradoxically, it thus seems that the expression of an autoreactive T cell receptor is a shared characteristic of T cells that are subject to clonal deletion and those that are diverted into the Treg cell lineage. Here, we discuss how thymocyte-intrinsic and -extrinsic determinants may specify the choice between these two fundamentally different T cell fates.

• Dokumententyp: Zeitschriftenartikel
• EU Funded Grant Agreement Number: 742290
• EU-Projekte: Horizon 2020 > ERC Grants > ERC Advanced Grant > ERC Grant 742290: TOLERANCE FOOTPRINT - Clonal Deletion versus Clonal Diversion: Footprints of Self-Tolerance in the T CellRepertoire
• Publikationsform: Postprint
• Keywords: T cell selection; central tolerance; clonal deletion; regulatory T cell; promiscuous gene expression
• Fakultät: Medizin > Institut für Immunologie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
• ISSN: 1474-1741
• Sprache: Englisch

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