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Klein, Ludger ORCID logoORCID: https://orcid.org/0000-0003-2054-071X; Robey, Ellen A. and Hsieh, Chyi-Song (January 2019): Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation. In: Nature Reviews Immunology, Vol. 19: pp. 7-18 [PDF, 1MB]

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The diversion of MHC class II-restricted thymocytes into the regulatory T (Treg) cell lineage, similarly to clonal deletion, is driven by intrathymic encounter of agonist self-antigens. Somewhat paradoxically, it thus seems that the expression of an autoreactive T cell receptor is a shared characteristic of T cells that are subject to clonal deletion and those that are diverted into the Treg cell lineage. Here, we discuss how thymocyte-intrinsic and -extrinsic determinants may specify the choice between these two fundamentally different T cell fates.

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