Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation

Klein, Ludger ; Robey, Ellen A. und Hsieh, Chyi-Song (January 2019): Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation. In: Nature Reviews Immunology, Vol. 19: pp. 7-18

Abstract

The diversion of MHC class II-restricted thymocytes into the regulatory T (Treg) cell lineage, similarly to clonal deletion, is driven by intrathymic encounter of agonist self-antigens. Somewhat paradoxically, it thus seems that the expression of an autoreactive T cell receptor is a shared characteristic of T cells that are subject to clonal deletion and those that are diverted into the Treg cell lineage. Here, we discuss how thymocyte-intrinsic and -extrinsic determinants may specify the choice between these two fundamentally different T cell fates.

• Item Type: Journal article
• EU Funded Grant Agreement Number: 742290
• EU Projects: Horizon 2020 > ERC Grants > ERC Advanced Grant > ERC Grant 742290: TOLERANCE FOOTPRINT - Clonal Deletion versus Clonal Diversion: Footprints of Self-Tolerance in the T CellRepertoire
• Form of publication: Postprint
• Keywords: T cell selection; central tolerance; clonal deletion; regulatory T cell; promiscuous gene expression
• Faculties: Medicine > Institute for Immunology
• Subjects: 500 Science > 570 Life sciences; biology
• ISSN: 1474-1741
• Language: English