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Aumueller, Nicole; Gruszfeld, Dariusz; Gradowska, Kinga; Escribano, Natalia and Martin; Poncelet, Pascale; Verduci, Elvira; ReDionigi, Alice; Koletzko, Berthold; Grote, Veit (2020): Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project. In: European journal of nutrition
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Abstract

PURPOSE We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. METHODS Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8~years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. RESULTS Data were available for 325 children. Children consumed on average 332~kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100~kcal from total sugar per day was significantly associated with a z score HDL-C decrease (-~0.14; 95% CI -~0.01, -~0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100~kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (-~1.67; 95% CI -~0.42, -~2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. CONCLUSION Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. CLINICAL TRIAL REGISTRY ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1.