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Beilner, Daniel; Kuhn, Christina; Kost, Bernd P.; Jückstock, Julia; Mayr, Doris; Schmoeckel, Elisa; Dannecker, Christian; Mahner, Sven; Jeschke, Udo and Heidegger, Helene Hildegard (2020): Lysine-specific histone demethylase 1A (LSD1) in cervical cancer. In: Journal of cancer research and clinical oncology, Vol. 146: pp. 2843-2850 [PDF, 1MB]


PURPOSE Demethylation of DNA through enzymes like LSD1 showed a crucial impact on different kind of cancers. Epigenetic modifications in cervical cancer are still not fully investigated nevertheless of high interest for a therapeutic use. METHODS Tumor samples of 250 cervical cancer patients were immunochemically stained and evaluated based on Immunoreactive Score. Results were statistically analyzed for clinical and pathological parameters. RESULTS Our patient collective showed a disadvantage for 10-year survival for patients with a strong expression of LSD1 in the cytoplasm of cervical cancer cells. The results of the correlational analysis further revealed a negative correlation of LSD1 to G-protein coupled estrogen receptor (GPER). CONCLUSIONS Epigenetic changes through enzymes like LSD1 may also be of interest for patients with cervical cancer. A combined therapy with other proteins relayed to cervical cancer like GPER might be of interest for future investigations.

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