Krause, Klaus-Henning; Berlit, Peter; Schmidt-Gayk, Heinrich; Schellenberg, Bernhard
Antiepileptic drugs reduce serum uric acid.
In: Epilepsy Research, Vol. 1, No. 5: pp. 306-307
Uric acid examination in 554 epileptic out-patients under long-term anticonvulsant medication revealed significantly lower serum concentrations compared to a group of normal controls. In patients taking enzyme-inducing drugs, uric acid levels were found to be lower than in those under valproate sodium. In addition, uric acid concentrations showed a negative correlation with duration of therapy in epileptic males. At this time, we can only speculate on the mechanism involved in the reduction of uric acid by enzyme-inducing anticonvulsants as well as on the possible implication of this finding in the treatment of hyperuricemia.