Self-Regeneration and Self-Healing in DNA Origami Nanostructures

Scheckenbach, Michael ; Schubert, Tom; Forthmann, Carsten; Glembockyte, Viktorija und Tinnefeld, Philip (November 2020): Self-Regeneration and Self-Healing in DNA Origami Nanostructures. In: Angewandte Chemie International Edition

Abstract

DNA nanotechnology and advances in the DNA origami technique have enabled facile design and synthesis of complex and functional nanostructures. Molecular devices are, however, prone to rapid functional and structural degradation due to the high proportion of surface atoms at the nanoscale and due to complex working environments. Besides stabilizing mechanisms, approach for the self‐repair of functional molecular devices are desirable. Here we exploit the self‐assembly and reconfigurability of DNA origami nanostructures to induce the self‐repair of defects of photoinduced and enzymatic damage. With different examples of repair in DNA nanostructures, we distinguish between unspecific self‐regeneration and damage specific self‐healing mechanisms. Using DNA origami nanorulers studied by atomic force and superresolution DNA PAINT microscopy, quantitative preservation of fluorescence properties is demonstrated with direct potential for improving nanoscale calibration samples.

• Dokumententyp: Zeitschriftenartikel
• EU Funded Grant Agreement Number: 737089
• EU-Projekte: Horizon 2020 > Marie Skłodowska Curie Actions > Marie Skłodowska-Curie Individual Fellowships
• Keywords: DNA; Molecular devices; Nanotechnology; Selfassembly; Self-Healing
• Fakultät: Chemie und Pharmazie > Department Chemie
• Fakultätsübergreifende Einrichtungen: Center for NanoScience (CENS)
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• Sprache: Englisch

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