Monofluorinated Nitrogen Containing Heterocycles: Synthesis, Characterization and Fluorine Effect

Reichel, Marco und Karaghiosoff, Konstantin (2020): Monofluorinated Nitrogen Containing Heterocycles: Synthesis, Characterization and Fluorine Effect. In: Zeitschrift für anorganische und allgemeine Chemie, Bd. 646, Nr. 22: S. 1790-1794

Abstract

A straight forward synthesis and efficient introduction of fluoromethyl group in nitrogen heterocycles is reported. Starting from the respective NH heterocycles fluoromethylation is performed with fluoroiodomethane and proceeds under mild reaction conditions. Structural information of monofluoromethylated nitrogen‐containing cyclic compounds containing the biologically active NCH2F moiety are reported. The particularly impressively change of physical and spectroscopic properties by the substitution of a methyl group by a monofluoromethyl group is discussed based on these examples.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• Sprache: Englisch