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Thurmaier, Johannes; Heinemann, Volker; Engel, Jutta; Schubert‐Fritschle, Gabriele; Wiedemann, Max; Nüssler, Natascha C.; Ruppert, Reinhard; Kleeff, Jörg; Schepp, Wolfgang; Löhe, Florian; Karthaus, Meinolf; Neumann, Jens; Kumbrink, Jörg; Taverna, Francesco; Stahler, Arndt ORCID logoORCID: https://orcid.org/0000-0003-1041-0137; Heinrich, Kathrin; Westphalen, Christoph Benedikt; Holch, Julian W.; Kirchner, Thomas and Michl, Marlies (28. October 2020): Patients with colorectal cancer and brain metastasis: The relevance of extracranial metastatic patterns predicting time intervals to first occurrence of intracranial metastasis and survival. In: International Journal of Cancer, Vol. 148, No. 8: pp. 1919-1927 [PDF, 619kB]


To investigate the predictive impact of extracranial metastatic patterns on course of disease and survival in patients with colorectal cancer (CRC) and brain metastasis (BM). A total of 228 patients (134 male [59%], 94 female [41%]) with histologically proven CRC and BM were classified into different groups according to extracranial metastatic patterns. Time intervals to metastatic events and survival times from initial CRC diagnosis, extracranial and intracranial metastasis were analyzed. Extracranial organs mostly affected were liver (102 of 228 [44.7%]) and lung (96 of 228 [42.1%]). Liver and lung metastasis were detected in 31 patients (13.6%). Calculated over the entire course of disease, patients with lung metastasis showed longer OS than patients with liver metastasis or patients without lung metastasis (43.9 vs. 34.6 [p=0.002] vs. 35.0 months [p=0.002]). From the date of initial CRC diagnosis, lung metastasis occurred later in CRC history than liver metastasis (24.3 vs. 7.5 months). Once lung metastasis was diagnosed BM occurred faster than in patients with liver metastasis (15.8 vs. 26.0 months; Δ 10.2 months). Accordingly, OS from the diagnosis of liver metastasis was longer than from lung metastasis (27.1 vs. 19.6 months [p=0.08]). Once BM was present patients with lung metastasis lived longer than patients with liver metastasis (3.8 vs. 1.1 months [p=0.028]). Shortest survival times in all survival categories analyzed revealed patients with concurrent liver and lung metastasis. Patients with CRC and BM form a heterogenous cohort where EM to liver or lung predict survival.

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