Tropschug, Maximilian; Nicholson, Donald W.; Hartl, Franz-Ulrich; Köhler, Helmut; Pfanner, Nikolaus; Wachter, Elmar; Neupert, Walter (5. Oktober 1988): Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa. One gene codes for both the cytosolic and mitochondrial forms. In: The Journal of Biological Chemistry, Vol. 263, Nr. 28: S. 14433-14440




Cyclophilin (cyclosporin A-binding protein) has a dual localization in the mitochondria and in the cytosol of Neurospora crassa. The two forms are encoded by a single gene which is transcribed into mRNAs having different lengths and 5' termini (approximately 1 and 0.8 kilobases). The shorter mRNA specifies the cytosolic protein consisting of 179 amino acids. The longer mRNA is translated into a precursor polypeptide with an amino-terminal extension of 44 amino acids which is cleaved in two steps upon entry into the mitochondrial matrix. Neurospora cyclophilin shows about 60% sequence homology to human and bovine cyclophilins.