Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis

Ostermann, Joachim; Horwich, Arthur; Neupert, Walter und Hartl, Franz-Ulrich (14. September 1989): Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. In: Nature, Bd. 341: S. 125-130

Abstract

Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1476-4687