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Ostermann, Joachim; Horwich, Arthur; Neupert, Walter and Hartl, Franz-Ulrich (14. September 1989): Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. In: Nature, Vol. 341: pp. 125-130 [PDF, 772kB]

Abstract

Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.

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