Ostermann, Joachim; Horwich, Arthur; Neupert, Walter; Hartl, Franz-Ulrich
(14. September 1989):
Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis.
In: Nature, Vol. 341: pp. 125-130
Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.