Protein sorting to mitochondria

Hartl, Franz-Ulrich and Neupert, Walter (23. February 1990): Protein sorting to mitochondria. Evolutionary conservations of folding and assembly. In: Science, Vol. 247, No. 4945: pp. 930-938

Abstract

According to the endosymbiont hypothesis, mitochondria have lost the autonomy of their prokaryotic ancestors. They have to import most of their proteins from the cytosol because the mitochondrial genome codes for only a small percentage of the polypeptides that reside in the organelle. Recent findings show that the sorting of proteins into the mitochondrial subcompartments and their folding and assembly follow principles already developed in prokaryotes. The components involved may have structural and functional equivalents in bacteria.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1095-9203