Pfanner, Nikolaus; Söllner, Thomas; Neupert, Walter
Mitochondrial import receptors for precursor proteins.
In: Trends in Biochemical Sciences, Vol. 16: pp. 63-67
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria. Recent studies have identified the mitochondrial outer membrane proteins MOM19, MOM72, MOM38 (≈ISP42) and p32 which have a role in initial steps of protein import. The first three components are present in a multi-subunit complex that catalyses recognition and membrane insertion of precursor proteins.