Abstract
We reviewed 47 documents published 1967-2019 that reported measurements of volatile organic compounds (VOCs) on commercial aircraft. We compared the measurements with the air quality standards and guidelines for aircraft cabins and in some cases buildings. Average levels of VOCs for which limits exist were lower than the permissible levels except for benzene with average concentration at 5.9±5.5 μg/m3. Toluene, benzene, ethylbenzene, formaldehyde, acetaldehyde, limonene, nonanal, hexanal, decanal, octanal, acetic acid, acetone, ethanol, butanal, acrolein, isoprene and menthol were the most frequently appearing compounds. The concentrations of SVOCs (Semi-Volatile Organic Compounds) and other contaminants did not exceed standards and guidelines in buildings except for the average NO2 concentration at 12 ppb. Although the focus was on VOCs, we also retrieved the data on other parameters characterizing cabin environment. Ozone concentration averaged 38±30 ppb below the upper limit recommended for aircraft. The outdoor air supply rate ranged from 1.7 to 39.5 L/s per person and averaged 6.0±0.8 L/s/p (median 5.8 L/s/p), higher than the minimum level recommended for commercial aircraft. Carbon dioxide concentration averaged 1,315±232 ppm, lower than what is permitted in aircraft and close to what is permitted in buildings. Measured temperatures averaged 23.5±0.8°C and were generally within the ranges recommended for avoiding thermal discomfort. Relative humidity averaged 16%±5%, lower than what is recommended in buildings.
Item Type: | Paper |
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EU Funded Grant Agreement Number: | 820872 |
EU Projects: | Horizon 2020 > Other > Joint Technology Initiative > Joint Technology Initiative - Clean Sky 2 |
Keywords: | Commercial aircraft, Cabin air quality, In-flight measurement, Contaminants, Thermal environment |
Faculties: | Medicine > Institute and Polyclinic for Occupational, Social and Environmental Medicine |
Subjects: | 600 Technology > 600 Technology 600 Technology > 610 Medicine and health 600 Technology > 620 Engineering |
URN: | urn:nbn:de:bvb:19-epub-76202-8 |
ISSN: | 2226-4310 |
Language: | English |
Item ID: | 76202 |
Date Deposited: | 11. Jun 2021, 08:00 |
Last Modified: | 24. Apr 2024, 09:34 |
References: | 1. Mazareanu E. Air transportation - Statistics & Facts. 2020. https://www.statista.com/topics/1707/air-transportation/.pdf Accessed Mar 4, 2020. 2. Mazareanu E. Global air traffic - scheduled passengers 2004-2020. 2020. https://www.statista.com/statistics/564717/airline-industry-passenger-traffic-globally/.pdf Accessed Jun 10, 2020. 3. Mazareanu E. Commercial airlines worldwide - fuel consumption 2005-2020. 2020. https://www.statista.com/statistics/655057/fuel-consumption-of-airlines-worldwide/.pdf Accessed Jun 10, 2020. 4. Rosero JA, Ortega JA, Aldabas E, Romeral L. Moving Towards a More Electric Aircraft. IEEE A&E Systems Magazine 2007: 3-9. 5. Aviation. How much air is recirculated (vs. bleed air injected) in modern airliners cabin? 2017. https://aviation.stackexchange.com/questions/43702/how-much-air-is-recirculated-vs-bleed-air-injected-in-modern-airliners-cabin.pdf Accessed 2017. 6. Fox RB. Air quality and comfort measurement aboard a commuter aircraft and solutions to improve perceived occupant comfort levels. In: Nagda, N.L. (ed.) Air Quality and Comfort in Airliner Cabins: ASTM STP 1393. West Conshohocken, PA, American Society for Testing and Materials 2000: 161–186. 7. NRCC. The Airliner Cabin Environment and the Health of Passengers and Crew. Washington (DC): National Academies Press (US); 2002. 344 p. 8. EASA. Certification Specifications and Acceptable Means of Compliance for Large Aeroplanes. 2003. 9. Zavaglio E, Le Cam M, Thibaud C, Quartarone G, Zhu Y, Franzini G, Roux PD, Dinca M, Walte A, Rothe P, (2019) Innovative Environmental Control System for Aircraft, 49th International Conference on Environmental Systems, 7-11 July 2019, Boston, Massachusetts. 10. EASA. CS-25 Certification Specifications and Acceptable Means of Compliance for Large Aeroplanes, Amendment 23. 2019. 11. Newman WH, Viele MR. Engine bleed air reduction in DC-10. 1980. 12. Liu W, Mazumdar S, Zhang Z, Poussou SB, Liu J, Lin C-H, Chen Q. State-of-the-art methods for studying air distributions in commercial airliner cabins. Building and Environment 2012; 47: 5-12. 13. Crump D. Air quality in aircraft: A continuing debate. Indoor and Built Environment 2016; 25: 725-727. 14. Rosenberger W. Effect of charcoal equipped HEPA filters on cabin air quality in aircraft. A case study including smell event related in-flight measurements. Building and Environment 2018; 143: 358-365. 15. Nagda NL, Rector HE. A critical review of reported air concentrations of organic compounds in aircraft cabins. Indoor Air 2003; 13: 292–301. 16. Lindgren T, Norbäck D. Health and perception of cabin air quality among Swedish commercial airline crew. Indoor Air 2005; 15. 17. Ahmadpour N, Lindgaard G, Robert J-M, Pownall B. The thematic structure of passenger comfort experience and its relationship to the context features in the aircraft cabin. Ergonomics 2014; 57: 801-815. 18. Harshada P, Mirabelle DC. Passenger-centric factors influencing the experience of aircraft comfort. Transport Reviews 2017; 38: 252-269. 19. Wolkoff P, Crump DR, Harrison PTC. Pollutant exposures and health symptoms in aircrew and office workers: Is there a link? Environment International 2016; 87: 74-84. 20. McNeely E, Gale S, Tager I, Kincl L, Bradley J, Coull B, Hecker S. The self-reported health of U.S. flight attendants compared to the general population. Environ Health 2014; 13: 13. 21. Griffiths RF, Powell DM. The occupational health and safety of flight attendants. Aviat Space Environ Med 2012; 83: 514-521. 22. Nagda NL, Rector HE, Li Z, Space DR. Aircraft Cabin Air Quality A Critical Review of Past Monitoring Studies. ASTM Spec. Tech. Publ. 2000. 23. Space DR, Johnson RA, Rankin WL, Nagda NL. The airplane cabin environment: Past, present and future research. ASTM Spec. Tech. Publ. 2000. 24. Lindgren T. Cabin Air Quality in Commercial Aircraft: Exposure, Symptoms and Signs. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1262. 2003. 25. FAA. 14 CFR 25,“Code of Federal Regulations,” Airworthiness Standards, Title 14, §25, Washington, DC. 1998. 26. ANSI/ASHRAE. ANSI/ASHRAE Standard 62, Ventilation for Acceptable Indoor Air Quality. Atlanta, GA. 1989. 27. Wolkoff P, Nielsen GD. Organic compounds in indoor air-their relevance for perceived indoor air quality? Atmospheric Environment 2001. 28. Norrefeldt V, Mayer F, Herbig B, Ströhlein R, Wargocki P, Fang L. Effect of Increased Cabin Recirculation Airflow Fraction on Relative Humidity, CO2 and TVOC. Aerospace 2021; 8. 29. Jones B, Amiri SN, Roth JW, Hosni M, (2016) The Nature of Particulates in Aircraft Bleed Air Resulting from Oil Contamination. 30. Weisel CP, Fiedler N, Weschler CJ, Ohman-Strickland PA, Mohan KR, McNeil K, Space DR. Human symptom responses to bioeffluents, short-chain carbonyls/acids, and long-chain carbonyls in a simulated aircraft cabin environment. Indoor Air 2017; 27: 1154-1167. 31. Solbu K, Daae HL, Thorud S, Ellingsen DG, Lundanes E, Molander P. Exposure to airborne organophosphates originating from hydraulic and turbine oils among aviation technicians and loaders. J Environ Monit 2010; 12: 2259-2268. 32. van Netten C. Air Quality and Health Effects Associated with the Operation of BAe 146-200 Aircraft. Applied Occupational and Environmental Hygiene 1998; 13: 733-739. 33. van Netten C. Design of a small personal air monitor and its application in aircraft. Sci Total Environ 2009; 407: 1206-1210. 34. Abraham MH, Sanchez-Moreno R, Cometto-Muniz JE, Cain WS. An algorithm for 353 odor detection thresholds in humans. Chem Senses 2012; 37: 207-218. 35. Nagata Y, Takeuchi N. Measurement of Odor Threshold by Triangle Odor Bag Method. Odor Measure Rev. 2003: 118-127. 36. ASHRAE. ANSI/ASHRAE Standard 161-2013, Air Quality within Commercial Aircraft, Atlanta. 2013. 37. FAA. Federal Aviation Regulations (FAR) Part 25 Airworthiness standards: Transport category airplanes, Washington. 2019. 38. JAA. Joint Airworthiness Requirements (Change 15) Part 25 Large Aeroplanes, Cheltenham: Civil Aviation Authority. 2007. 39. ASD-STAN. prEN 4618: 2013 Aerospace series-aircraft internal air quality standards: criteria and determination methods,Brussels: ASD-STAN. 2013. 40. IAC. Aviation Regulations (AP) Part 25 Airworthiness standards for Transport category Airplanes (in Russia). 2005. 41. CCAC. Chinese civil aviation regulations Part 25 airworthiness standards for transport aircraft, Order of CAAC no. 19 of 2016. 2016. 42. Wanner H-U, Verhoeff A, Colombi A, Flannigan B, Gravesen S, Mouileseaux A, Nevalainen A, Papadakis J, Seide K. Biological particles in Indoor Environments. European Collaborative Action, Indoor air quality and its impact on man. Commission of the European Communities, Luxembourg, 1993. 43. EU, BIA. ‘Guidelines workplace, Germany' according EU frame-guidelines 89/391; BIA’s report 2/95 'Indoor Air Quality’, Germany. 44. ASHRAE. ASHRAE Handbook HVAC Applications. 2019. 45. Park MY. These Are the Healthiest Planes in the Sky. 2018. https://thepointsguy.com/news/the-healthiest-planes-in-the-air-today/ Accessed May 7, 2018. 46. Reed T. Twenty-five Years Ago, U.S. Airlines Banned Smoking On Domestic Flights. Aerospace and Defense 2015. 47. Lindgren T, Norbäck D. Cabin air quality indoor pollutants and climate during intercontinental flights with and without tobacco smoking. Indoor Air 2002; 12: 263-272. 48. Brabets RI, Hersh CK, Klein MJ. Ozone measurement survey in commercial jet aircraft. Journal of Aircraft 1967; 4: 59-64. 49. Bischof W. Ozone measurements in jet airliner cabin air. Water, Air, and Soil Pollution 1973; 2: 3-14. 50. Perkins PJ, Holdeman JD, Nastrom GD. Simultaneous Cabin and Ambient Ozone Measurements on Two Boeing 747 Airplanes. 1979. 51. Rogers JW. Results of FAA cabin ozone monitoring program in commercial aircraft in 1978 and 1979. 1980. 52. Nagda NL, Koontz MD, Konheim AG, Hammond SK. Measurement of cabin air quality aboard commercial airliner. Atmospheric Environment 1992; 26: 2203-2210. 53. Dechow M, Sohn H, Steinhanses J. Concentrations of selected contaminants in cabin air of airbus aircrafts. Chemosphere 1997; 35: 21-31. 54. ASHRAE, CSS. Relate Air Quality and Other Factors to Symptoms Reported by Passengers and Crew on Commercial Transport Category Aircraft. 1999. 55. Lee S-C, Poon C-S, Li X-D, Luk F. Indoor Air Quality Investigation on Commercial Aircraft. Indoor Air 1999; 9: 180-187. 56. Haghighat F, Allard F, Megri AC, Blondeau P, Shimotakahara R. Measurement of thermal comfort and indoor air quality aboard 43 flights on commercial airlines. Indoor and Built and Environment 1999; 8: 58-66. 57. Dumyahn TS, Spengler JD, Burge HA, Muilenburg M. Comparison of the environments of transporation vehicles: results of two surveys. In: Nagda, N.L. (ed.) Air Quality and Comfort in Airliner Cabins: ASTM STP 1393. West Conshohocken, PA, American Society for Testing and Materials 2000: 3–23. 58. Ree dH, Bagshaw M, Simons R, Brown RA. Ozone and relative humidity in airline cabins on polar routes measurements and physical symptoms. ASTM Spec. Tech. Publ. 2000. 59. Wieslander G, Lindgren T, Norback D, Venge P. Changes in the ocular and nasal signs and symptoms of aircrews in relation to the ban on smoking on intercontinental flights. Scand J Work Environ Health 2000; 26: 514-522. 60. Nagda NL, Rector HE, Li Z, Hunt EH. Determine Aircraft Supply Air Contaminants in the Engine Bleed Air Supply System on Commercial Aircraft. 1791 Tullie Circle, NE, Atlanta, GA 30329-2305; 2001. 61. Waters MA, Bloom TF, Grajewski B, Deddens J. Measurements of indoor air quality on commercial transport aircraft. Proceedings: Indoor Air 2002 2002. 62. Spicer CW, Murphy MJ, Holdren MW, Myers JD, MacGregor IC, Holloman C, James RR, Tucker K, Zaborski R. Relate Air Quality and Other Factors to Comfort and Health Symptoms Reported by Passengers and Crew on Commercial Transport Aircraft (Part I) (ASHRAE Project 1262-TRP). 2004. 63. Spengler JD, Ludwig S, Weker RA. Ozone exposures during trans-continental and trans-pacific flights. Indoor Air 2004; 14: 67–73. 64. Duc ML, Stuecker T, Venkateswaran K. Molecular bacterial diversity and bioburden of commercial airliner cabin air. Canadian Journal of Microbiology 2007; 53: 1259-1271. 65. Bhangar S, Cowlin SC, Singer BC, Sextro RG, Nazaroff WW. Ozone levels in passenger cabins of commercial aircraft on North American and transoceanic. Environmental Science & Technology 2008; 42: 3938-3943. 66. Muir H, Walton C, Mckeown R. Cabin Air Sampling Study Functionality Test. Cranfield University School of Engineering 2008. 67. McKernan LT, Wallingford KM, Hein MJ, Burge H, Rogers CA, Herrick R. Monitoring microbial populations on wide-body commercial passenger aircraft. Annals of Occupational Hygiene 2008; 52: 139-149. 68. Osman S, Duc ML, Dekas A, Newcombe D, Venkateswaran K. Microbial burden and diversity of commercial airline cabin air during short and long durations of travel. The ISME Journal 2008; 2: 482-497. 69. Solbu K, Daae HL, Olsen R, Thorud S, Ellingsen DG, Lindgren T, Bakke B, Lundanes E, Molander P. Organophosphates in aircraft cabin and cockpit air-method development and measurements of contaminants. Journal of Environmental Monitoring 2011; 13: 1393-1403. 70. Crump D, Harrison P, Walton C. Aircraft Cabin Air Sampling Study; Part 1 of the Final Report. Institute of Environment and Health report 2011. 71. Crump D, Harrison P, Walton C. Aircraft Cabin Air Sampling Study; Part 2 of the Final Report. Institute of Environment and Health report 2011. 72. Spengler JD, Vallarino J, McNeely E, Estephan H. In-Flight/Onboard Monitoring: ACER’s Component for ASHRAE 1262, Part 2. Final Report, 2005-2010. 2012. 73. Gładyszewska-Fiedoruk K. Indoor air quality in the cabin of an airliner. Journal of Air Transport Management 2012; 20: 0-30. 74. Giaconia C, Orioli A, Gangi AD. Air quality and relative humidity in commercial aircrafts: An experimental investigation on short-haul domestic flights. Building and Environment 2013; 67: 69-81. 75. Weisel C, Weschler CJ, Mohan K, Vallarino J, Spengler JD. Ozone and Ozone Byproducts in the Cabins of Commercial Aircraft. Environmental Science & Technology 2013; 47: 4711-4717. 76. Ji W, Zhao B. Estimation of the contribution of secondary organic aerosol to PM2.0 concentration in aircraft cabins. Building and Environment 2014; 82: 267-273. 77. Guan J, Gao K, Wang C, Yang X, Lin C-H, Lu C, Gao P. Measurements of volatile organic compounds in aircraft cabins. Part I: Methodology and detected VOC species in 107 commercial flights. Building and Environment 2014; 72: 154-161. 78. Guan J, Wang C, Gao K, Yang X, Lin C-H, Lu C. Measurements of volatile organic compounds in aircraft cabins. Part II: Target list, concentration levels and possible influencing factors. Building and Environment 2014; 75: 170-175. 79. Li Z, Guan J, Yang X, Lin C-H. Source apportionment of airborne particles in commercial aircraft cabin environment: Contributions from outside and inside of cabin. Atmospheric Environment 2014; 89: 119-128. 80. Ree HD, Martin VDB, Brand T, Mulder GJ, Simons R, Brinio VVZ, Westerink RHS. Health risk assessment of exposure to TriCresyl Phosphates (TCPs) in aircraft: a commentary. Neurotoxicology 2014; 45: 209-215. 81. Wang C, Yang X, Guan J, Gao K, Li Z. Volatile organic compounds in aircraft cabin: Measurements and correlations between compounds. Building and Environment 2014; 78: 89-94. 82. Wang C, Yang X, Guan J, Li Z, Gao K. Source apportionment of volatile organic compounds (VOCs) in aircraft cabins. Building and Environment 2014; 81: 1-6. 83. Guan J, Li Z, Yang X. Net in-cabin emission rates of VOCs and contributions from outside and inside the aircraft cabin. Atmospheric Environment 2015; 111: 1-9. 84. Gao K, Xie J, Yang X. Estimation of the contribution of human skin and ozone reaction to volatile organic compounds (VOC) concentration in aircraft cabins. Building and Environment 2015; 94: 12-20. 85. Rosenberger W, Beckmann B, Wrbitzky R. Airborne aldehydes in cabin-air of commercial aircraft: Measurement by HPLC with UV absorbance detection of 2,4-dinitrophenylhydrazones. J Chromatogr B Analyt Technol Biomed Life Sci 2016; 1019: 117-127. 86. Schuchardt S, Bitsch A, Koch W, Rosenberger W. CAQ Preliminary cabin air quality measurement campaign. 2017. https://www.easa.europa.eu/sites/default/files/dfu/EASA%20CAQ%20Study%20Final%20Report_21.03.2017.pdf Accessed 2017. 87. Cao Q, Xu Q, Liu W, Lin C-H, Wei D, Baughcum S, Norris S, Chen Q. In-flight monitoring of particle deposition in the environmental control systems of commercial airliners in China. Atmospheric Environment 2017; 154: 118-128. 88. Cao X, Zevitas CD, Spengler JD, Coull B, McNeely E, Jones B, Loo SM, MacNaughton P, Allen JG. The on-board carbon dioxide concentrations and ventilation performance in passenger cabins of US domestic flights. Indoor and Built Environment 2018; 28: 761-771. 89. Schuchardt S, Koch W, Rosenberger W. Cabin air quality-Quantitative comparison of volatile air contaminants at different flight phases during 177 commercial flights. Building and Environment 2019; 148: 498-507. 90. Guan J, Jia Y, Wei Z, Tian X. Temporal variations of ultrafine particle concentrations in aircraft cabin: A field study. Building and Environment 2019; 153: 118-127. 91. Liu M, Liu J, Ren J, Liu L, Chen R, Li R. Bacterial community in commercial airliner cabins in China. Int J Environ Health Res 2019: 1-12. 92. MacGregor IC, Spicer CW, Buehler SS. Concentrations of Selected Chemical Species in the Airliner Cabin Environment. Journal of ASTM International 2008; 5. 93. OEHHA. OEHHA Acute, 8-hour and Chronic Reference Exposure Level (REL) Summary. 2019. 94. WHO. WHO guidelines for indoor air quality: selected pollutants. 2010. 95. Wisthaler A, Tamas G, Wyon D, Strom-Tejsen P, Space D, Beauchamp J, Hansel A, Mark T, Weschler C. Products of Ozone-Initiated Chemistry in a Simulated Aircraft Environment. Environ. Sci. Technol. 2005; 39: 4823-4832. 96. Weschler CJ, Wisthaler A, Cowlin S, Tamás G, Strøm-Tejsen P, Hodgson AT, Destaillats H, Herrington J, Zhang J, Nazaroff WW. Ozone-Initiated Chemistry in an Occupied Simulated Aircraft Cabin. Environ. Sci. Technol. 2007; 41: 6177-6184. 97. Norgaard AW, Kudal JD, Kofoed-Sorensen V, Koponen IK, Wolkoff P. Ozone-initiated VOC and particle emissions from a cleaning agent and an air freshener: risk assessment of acute airway effects. Environ Int 2014; 68: 209-218. 98. Singer BC, Coleman BK, Destaillats H, Hodgson AT, Lunden MM, Weschler CJ, Nazaroff WW. Indoor secondary pollutants from cleaning product and air freshener use in the presence of ozone. Atmospheric Environment 2006; 40: 6696-6710. 99. Sun J. D-Limonene: Safety and Clinical Applications. Alternative Medicine Review 2007; 12: 259-264. 100. Orth A-M, Lu Y, Engel K-H. Assessment of dietary exposure to flavouring substances via consumption of flavoured teas. Part 1: occurrence and contents of monoterpenes in Earl Grey teas marketed in the European Union. Food Additives & Contaminants: Part A 2013; 30: 1701-1714. 101. Simpson S, Roux P, Dinca M. The science behind sensing and filtering cabin air. AST 2019, February 19-20, Hamburg, Germany 2019. 102. Wainman T, Zhang J, Weschler CJ, Lioy PJ. Ozone and Limonene in Indoor Air: A Source of Submicron Particle Exposure. Environmental Health Perspectives 2001; 108: 1139-1145. 103. Langer S, Moldanová J, Arrhenius K, Ljungström E, Ekberg L. Ultrafine particles produced by ozone/limonene reactions in indoor air under low/closed ventilation conditions. Atmospheric Environment 2008; 42: 4149-4159. 104. Rai AC, Guo B, Lin CH, Zhang J, Pei J, Chen Q. Ozone reaction with clothing and its initiated VOC emissions in an environmental chamber. Indoor Air 2014; 24: 49-58. 105. Tsushima S, Wargocki P, Tanabe S. Sensory evaluation and chemical analysis of exhaled and dermally emitted bioeffluents. Indoor Air 2018; 28: 146-163. 106. MHLW. Committee on Sick House Syndrome: Indoor Air Pollution Progress Report No. 4. 2002. http://www.nihs.go.jp/mhlw/chemical/situnai/kentoukai/rep-eng4.pdf Accessed 2002. 107. MHEPA. GB 18883-2002 indoor air quality standard. 2002. 108. AHSD. Residential indoor air quality guidelines. 2018. 109. AOLG. German Committee on Indoor Guide Values. 2018. 110. ACGIH. Risks of Hazardous Wastes. Appendix F-ACGIH Threshold Limit Value (TLV). 2011. 111. NIOSH. NIOSH pocket guide to chemical hazards. 2005. 112. Winder C, Balouet JC. The toxicity of commercial jet oils. Environmental Research 2002; 89: 0-164. 113. CAA. Cabin air quality-CAA paper 2004/04. 2004. 114. Winder C, Michaelis S. Crew Effects from Toxic Exposures on Aircraft. The Handbook of Environmental Chemistry 2005; 4H: 229-248. 115. Maddalena RL, Mckone TE. Insecticide exposures on commercial aircraft A literature review and screening level assessment. Lawrence Berkeley National Laboratory 2008. 116. Denola G, Hanhela PJ, Mazurek W. Determination of tricresyl phosphate air contamination in aircraft. Ann Occup Hyg 2011; 55. 117. Howard CV, Johnson DW, Morton J, Michaelis S, Supplee D, Burdon J. Is a Cumulative Exposure to a Background Aerosol of Nanoparticles Part of the Causal Mechanism of Aerotoxic Syndrome? J Nanomed Nanosci: JNAN-139. 2018; 2018. 118. Marsillach J, Richter RJ, Kim JH, Stevens RC, MacCoss MJ, Tomazela D, Suzuki SM, Schopfer LM, Lockridge O, Furlong CE. Biomarkers of organophosphorus (OP) exposures in humans. Neurotoxicology 2011; 32: 656-660. 119. Cheng MD. Classification of Volatile Engine Particles. Aerosol and Air Quality Research 2013; 13: 1411-1422. 120. TRGS. Technical Rules for Hazardous Substances. 2006. https://www.baua.de/DE/Angebote/Rechtstexte-und-Technische-Regeln/Regelwerk/TRGS/pdf/TRGS-900.pdf?__blob=publicationFile Accessed 2006. 121. Nicholson TT, Sznajder JI. Fitness to fly in patients with lung disease. Ann Am Thorac Soc 2014; 11: 1614-1622. 122. Begum E, Metin A, Grazia P, Stefano N. Should I stay or should I go? COPD and air travel. Eur Respir Rev 2018; 27. 123. Yates EL, Johnson MS, Iraci LT, Ryoo JM, Pierce RB, Cullis PD, Gore W, Ives MA, Johnson BJ, Leblanc T, Marrero JE, Sterling CW, Tanaka T. An Assessment of Ground Level and Free Tropospheric Ozone Over California and Nevada. Journal of Geophysical Research: Atmospheres 2017; 122: 10089-10102. 124. Bhangar S, Nazaroff WW. Atmospheric ozone levels encountered by commercial aircraft on transatlantic routes. ENVIRONMENTAL RESEARCH LETTERS 2013; 8. 125. WHO. WHO Air quality guidelines for particulate matter, ozone, nitrogen dioxide and sulfur dioxide. 2005. 126. Machida T, Kita K, Kondo Y, Blake D, Kawakami S, Inoue G, Ogawa T. Vertical and meridional distributions of the atmospheric CO2mixing ratio between northern midlatitudes and southern subtropics. Journal of Geophysical Research 2002; 108. 127. Foucher PY, Chédin A, Armante R, Boone C, Crevoisier C, Bernath P. First carbon dioxide atmospheric vertical profiles retrieved from space observation using ACE-FTS solar occultation instrument. Atmospheric Chemistry and Physics Discussions 2010; 10: 26473-26512. 128. Tuzson B, Henne S, Brunner D, Steinbacher M, Mohn J, Buchmann B, Emmenegger L. Continuous isotopic composition measurements of tropospheric CO2 at Jungfraujoch (3580 m a.s.l.), Switzerland: real-time observation of regional pollution events. Atmospheric Chemistry and Physics 2011; 11: 1685-1696. 129. Sawa Y, Matsueda H, Makino Y, Inoue HY, Murayama S, Hirota M, Tsutsumi Y, Zaizen Y, Ikegami M, Okada K. Aircraft Observation of CO2, CO2 O3 and H2 over the North Pacific during the PACE-7 Campaign. Tellus B: Chemical and Physical Meteorology 2017; 56: 2-20. 130. ANSI/ASHRAE. ANSI/ASHRAE Standard 62.1, Ventilation for Acceptable Indoor Air Quality. 2016. 131. Fisk W, Wargocki P, Zhang X. Do Indoor CO2 Levels Directly Affect Perceived Air Quality, Health, or Work Performance? ASHRAE Journal 2019; 61. 132. Du B, Tandoc MC, Mack ML, Siegel JA. Indoor CO2 concentrations and cognitive function: A critical review. Indoor Air 2020; 30: 1067-1082. 133. CEN. EN 16798‑1: 2019. Energy performance of buildings-Ventilation for buildings. 2019. 134. ASTM. ASTM D6399-18. Standard guide for selecting instruments and methods for measuring air quality in aircraft cabins. Designation: D6399-18. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959. United States; 2018. 135. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods,. 3rd edition, Vol. 1, National Technical Information Service, Springfield, VA, 1984. 136. U.S. Environmental Protection Agency. EPA Compendium of Methods for the Determination of Toxic Organic Compounds in Ambient Air: Methods TO-1 through TO-14. published from 1984 through 1988. 137. ISO 16000-6. Indoor air-Part 6: Determination of volatile organic compounds in indoor and test chamber air by active sampling on Tenax TA sorbent, thermal desorption and gas chromatography using MS/FID. 2004. 138. BS EN ISO 16017-1. Indoor, ambient and workplace air sampling and analysis of volatile organic compounds by sorbent tube thermal desorption capillary gas chromatography Part 1 Pumped sampling. 2001. |