Impact of Treatment with RUTF on Plasma Lipid Profiles of Severely Malnourished Pakistani Children

Shokry, Engy; Sadiq, Kamran; Soofi, Sajid; Habib, Atif; Bhutto, Naveed; Rizvi, Arjumand; Ahmad, Imran; Demmelmair, Hans; Uhl, Olaf; Bhutta, Zulfiqar A. und Koletzko, Berthold (21. Juli 2020): Impact of Treatment with RUTF on Plasma Lipid Profiles of Severely Malnourished Pakistani Children. In: Nutrients, Bd. 12, Nr. 7, 2163

Abstract

(1) Background: Little is known on impacts of ready-to-use therapeutic food (RUTF) treatment on lipid metabolism in children with severe acute malnutrition (SAM). (2) Methods: We analyzed glycerophospholipid fatty acids (FA) and polar lipids in plasma of 41 Pakistani children with SAM before and after 3 months of RUTF treatment using gas chromatography and flow-injection analysis tandem mass spectrometry, respectively. Statistical analysis was performed using univariate, multivariate tests and evaluated for the impact of age, sex, breastfeeding status, hemoglobin, and anthropometry. (3) Results: Essential fatty acid (EFA) depletion at baseline was corrected by RUTF treatment which increased EFA. In addition, long-chain polyunsaturated fatty acids (LC-PUFA) and the ratio of arachidonic acid (AA)/linoleic acid increased reflecting greater EFA conversion to LC-PUFA, whereas Mead acid/AA decreased. Among phospholipids, lysophosphatidylcholines (lyso.PC) were most impacted by treatment; in particular, saturated lyso.PC decreased. Higher child age and breastfeeding were associated with great decrease in total saturated FA (ΣSFA) and lesser decrease in monounsaturated FA and total phosphatidylcholines (ΣPC). Conclusions: RUTF treatment improves EFA deficiency in SAM, appears to enhance EFA conversion to biologically active LC-PUFA, and reduces lipolysis reflected in decreased ΣSFA and saturated lyso.PC. Child age and breastfeeding modify treatment-induced changes in ΣSFA and ΣPC.

• Dokumententyp: Zeitschriftenartikel
• EU Funded Grant Agreement Number: 733206
• EU-Projekte: Horizon 2020 > RIA - Research and Innovation action > LIFECYCLE - Early-life stressors and LifeCycle health
• Publikationsform: Publisher's Version
• Fakultät: Medizin > Klinikum der LMU München > Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch