Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia

Papaioannou, Dimitrios; Ozer, Hatice G.; Nicolet, Deedra; Urs, Amog P.; Herold, Tobias; Mrózek, Krzysztof; Batcha, Aarif M. N.; Metzeler, Klaus H.; Yilmaz, Ayse S.; Volinia, Stefano; Bill, Marius; Kohlschmidt, Jessica; Pietrzak, Maciej; Walker, Christopher J.; Carroll, Andrew J.; Braess, Jan; Powell, Bayard L.; Eisfeld, Ann-Kathrin; Uy, Geoffrey L.; Wang, Eunice S.; Kolitz, Jonathan E.; Stone, Richard M.; Hiddemann, Wolfgang; Byrd, John C.; Bloomfield, Clara D. und Garzon, Ramiro (2021): Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia. In: Haematologica

Abstract

Expression levels of long non-coding RNAs (lncRNAs) have been shown to associate with clinical outcome of patients with cytogenetically normal acute myeloid leukemia (CN-AML). However, the frequency and clinical significance of genetic variants in the nucleotide sequences of lncRNAs in AML patients is unknown. Herein, we analyzed total RNA sequencing data of 377 younger adults (aged.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch