Ahluwalia, Tarunveer S.; Prins, Bram P.; Abdollahi, Mohammadreza; Armstrong, Nicola J.; Aslibekyan, Stella; Bain, Lisa; Jefferis, Barbara; Baumert, Jens; Beekman, Marian; Ben-Shlomo, Yoav; Bis, Joshua C.; Mitchell, Braxton D.; Geus, Eco de; Delgado, Graciela E.; Marek, Diana; Eriksson, Joel; Kajantie, Eero; Kanoni, Stavroula; Kemp, John P.; Lu, Chen; Marioni, Riccardo E.; McLachlan, Stela; Milaneschi, Yuri; Nolte, Ilja M.; Petrelis, Alexandros M.; Porcu, Eleonora; Sabater-Lleal, Maria; Naderi, Elnaz; Seppälä, Tina and Singhal; Spector, Tim; Stacey, David; Stathopoulou, Maria G.; Tanaka, Toshiko; Wannamethee, S. Goya; Whincup, Peter; Rotter, Jerome I.; Dehghan, Abbas; Boerwinkle, Eric; Psaty, Bruce M.; Snieder, Harold; Alizadeh, Behrooz Z.; Müller-Nurasyid, Martina (2021): Genome-wide association study of circulating interleukin 6 levels identifies novel loci. In: Human Molecular Genetics, Vol. 30, No. 5: pp. 393-409 |
| Creative Commons Attribution 1MB |
Abstract
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 × 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcombined = 1.5 × 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (Pcombined = 1.2 × 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
Item Type: | Journal article |
---|---|
Faculties: | Medicine > Institute for Medical Information Processing, Biometry and Epidemiology |
Subjects: | 600 Technology > 610 Medicine and health |
URN: | urn:nbn:de:bvb:19-epub-78000-7 |
Annotation: | Vollständige Autor*innen-Liste s. Volltext |
Language: | English |
ID Code: | 78000 |
Deposited On: | 03. Dec 2021 07:09 |
Last Modified: | 03. Dec 2021 07:09 |
- BASE
- Ahluwalia, Tarunveer S.
- Prins, Bram P.
- Abdollahi, Mohammadreza
- Armstrong, Nicola J.
- Aslibekyan, Stella
- Bain, Lisa
- Jefferis, Barbara
- Baumert, Jens
- Beekman, Marian
- Ben-Shlomo, Yoav
- Bis, Joshua C.
- Mitchell, Braxton D.
- Geus, Eco de
- Delgado, Graciela E.
- Marek, Diana
- Eriksson, Joel
- Kajantie, Eero
- Kanoni, Stavroula
- Kemp, John P.
- Lu, Chen
- Marioni, Riccardo E.
- McLachlan, Stela
- Milaneschi, Yuri
- Nolte, Ilja M.
- Petrelis, Alexandros M.
- Porcu, Eleonora
- Sabater-Lleal, Maria
- Naderi, Elnaz
- Seppälä, Tina and Singhal
- Spector, Tim
- Stacey, David
- Stathopoulou, Maria G.
- Tanaka, Toshiko
- Wannamethee, S. Goya
- Whincup, Peter
- Rotter, Jerome I.
- Dehghan, Abbas
- Boerwinkle, Eric
- Psaty, Bruce M.
- Snieder, Harold
- Alizadeh, Behrooz Z.
- Müller-Nurasyid, Martina
- Google Scholar
- Ahluwalia, Tarunveer S.
- Prins, Bram P.
- Abdollahi, Mohammadreza
- Armstrong, Nicola J.
- Aslibekyan, Stella
- Bain, Lisa
- Jefferis, Barbara
- Baumert, Jens
- Beekman, Marian
- Ben-Shlomo, Yoav
- Bis, Joshua C.
- Mitchell, Braxton D.
- Geus, Eco de
- Delgado, Graciela E.
- Marek, Diana
- Eriksson, Joel
- Kajantie, Eero
- Kanoni, Stavroula
- Kemp, John P.
- Lu, Chen
- Marioni, Riccardo E.
- McLachlan, Stela
- Milaneschi, Yuri
- Nolte, Ilja M.
- Petrelis, Alexandros M.
- Porcu, Eleonora
- Sabater-Lleal, Maria
- Naderi, Elnaz
- Seppälä, Tina and Singhal
- Spector, Tim
- Stacey, David
- Stathopoulou, Maria G.
- Tanaka, Toshiko
- Wannamethee, S. Goya
- Whincup, Peter
- Rotter, Jerome I.
- Dehghan, Abbas
- Boerwinkle, Eric
- Psaty, Bruce M.
- Snieder, Harold
- Alizadeh, Behrooz Z.
- Müller-Nurasyid, Martina