Clinical impact of elevated tricuspid valve inflow gradients after transcatheter edge to-edge tricuspid valve repair

Orban, Martin; Orban, Mathias W.; Braun, Daniel; Deseive, Simon; Kupka, Danny; Stocker, Thomas J.; Bagaev, Erik; Karam, Nicole; Hagl, Christian; Massberg, Steffen; Nabauer, Michael und Hausleiter, Jörg (2019): Clinical impact of elevated tricuspid valve inflow gradients after transcatheter edge to-edge tricuspid valve repair. In: Eurointervention, Bd. 15, Nr. 12

Abstract

Aims: The aim of study was to compare the outcome of patients with a post-procedural tricuspid valve gradient (TVG) of >3 mmHg vs <= 3 mmHg after transcatheter edge-to-edge tricuspid valve repair (TTVR). Methods and results: Between March 2016 and October 2018 we treated 145 patients with severe tricuspid regurgitation (TR) with TTVR by placing 2.21 +/- 0.7 clips per patient. Device success (TR reduction >= 1 degrees to at least moderate) was achieved in 125 patients (86.2%). TTVR resulted in an elevated TVG >3 mmHg in 25 (17.2%) patients. Device success (84% vs 86.7%, p=0.9), number of clips implanted (2.3 +/- 0.7 vs p=0.33), clinical improvement including NYHA class (III/IV 24% vs 28%, p=0.92) and increase in six-minute walking test at one month (67 m [IQR 5-103 m] vs 56 m [IQR 8-97 m], p=0.93), mortality (HR 1.07, 95% CI: 0.43-2.65, P-logrank =0.88) and the combined endpoint mortality and hospitalisation for heart failure at one year (BR 1.07, 95% CI: 0.46-2.48, P-logrank =0.88) were similar between patients with a TVG >3 mmHg versus patients with a TVG <= 3 mmHg. Conclusions: A small cohort of patients demonstrated an elevated TVG higher than 3 mmHg at discharge. This elevation had no impact on clinical improvement, mortality or hospitalisation for heart failure.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1774-024X
• Sprache: Englisch