Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer

Musa, Julian und Grünewald, Thomas G. P. (2019): Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer. In: Molecular & Cellular Oncology, Bd. 7, Nr. 1, e1682924

Abstract

Deciphering principles of inter-tumoral heterogeneity is crucial for refinement of precision oncology. We have recently demonstrated that 'oncogenic cooperation' between somatic mutations and regulatory germline variants can serve as a major cause for inter-tumoral heterogeneity, suggesting the requirement of integrating the regulatory genome into 'omics'-based precision oncology.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch