Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer

Musa, Julian and Grünewald, Thomas G. P. (2019): Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer. In: Molecular & Cellular Oncology, Vol. 7, No. 1, e1682924

Abstract

Deciphering principles of inter-tumoral heterogeneity is crucial for refinement of precision oncology. We have recently demonstrated that 'oncogenic cooperation' between somatic mutations and regulatory germline variants can serve as a major cause for inter-tumoral heterogeneity, suggesting the requirement of integrating the regulatory genome into 'omics'-based precision oncology.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• Language: English