Emerging strategies in neoadjuvant treatment of patients with HER2-positive early breast cancer

Harbeck, Nadia (2019): Emerging strategies in neoadjuvant treatment of patients with HER2-positive early breast cancer. In: Breast, Bd. 48: S97-S102

Abstract

The St. Gallen Consensus 2017 recommended neoadjuvant therapy as a standard of care in stage II-III HER2-positive (HER2+) early breast cancer (EBC). Today, the neoadjuvant approach has become even more clinically relevant, as pathological complete response (pCR) status can not only be used to predict patient outcome, but also to escalate anti-HER2 therapy after surgery, based on the recently published results from the KATHARINE trial. Based on the NEOSPHERE results, dual antibody blockade together with chemotherapy has become the neoadjuvant standard. The chemotherapy backbone consists either of an anthracycline-taxane sequence or of an anthracycline-free regimen such as docetaxel and carboplatin. Adjuvant anti-HER2 therapy is then chosen based on initial tumor burden and pCR status. A multidisciplinary approach right from the beginning guarantees optimal treatment results for patients with HER2+ EBC. Emerging strategies will include early response markers (e.g. biomarkers, molecular imaging) as well as novel targeted agents (e.g. immunotherapy) in order to individualize systemic therapy in HER2-positive EBC. Neoadjuvant and adjuvant therapy thus represent components of an integrated, continuous strategy in HER2+ EBC allowing therapy adaptation according to individual tumor response. Refining the treatment algorithm with further de-escalation and escalation approaches will hopefully lead to better chances for cure as well as reduced short- and long-term toxicities in HER2-positive early breast cancer. (C) 2019 Elsevier Ltd. All rights reserved.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0960-9776
• Sprache: Englisch