Vessel adherent growth represents a major challenge in the surgical resection of neuroblastoma and Is associated with adverse outcome

Mühling, Jakob; Eberherr, Corinna; Höcker, Josef Müller; Grote, Veit; Schweinitz, Dietrich von; Kappler, Roland und Froeba-Pohl, Alexandra (2019): Vessel adherent growth represents a major challenge in the surgical resection of neuroblastoma and Is associated with adverse outcome. In: Journal of Pediatric Surgery, Bd. 54, Nr. 11: S. 2336-2342

Abstract

Purpose: Neuroblastoma (NB) is the most common extracranial, solid tumor in childhood, with a peak incidence in children under 6 years of age. Due to its variable course of disease, which ranges from spontaneous regression to metastatic spread, NB still represents a significant therapeutic challenge. Strikingly, a certain number of NBs intraoperatively show vessel adhesion and/or infiltrative growth, which is often not visible in pre-operative imaging. We proposed the term unexpected vessel infiltration of NB (UVIN) to denote this phenomenon. UVIN represents a major surgical challenge. Methods: In this study, we determined frequency and clinical relevance of UVIN in a cohort of 100 NB-patients with subsequent correlation to several unfavorable characteristics of disease. RNA expression levels of MYCN and its co-regulated antisense transcript MYCNOS to identify markers was measured by PCR. Results: We found UVIN to be present in 34% of cases and significantly correlated with incomplete resection, MYCN amplification, complications, neoadjuvant therapy, tumor grade and MYCNOS expression levels. MYCN expression levels showed no significant results with UVIN. Conclusion: Collectively, our data show that UVIN represents a frequent surgical problem associated with a poor outcome in NB patients. MYCN and MYCNOS seem to be no appropriate markers for UVIN. Type of study: Prognosis study. (C) 2019 Elsevier Inc. All rights reserved.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0022-3468
• Sprache: Englisch