Endocrine responses during CPAP withdrawal in obstructive sleep apnoea: data from two randomised controlled trials

Thiel, Sira; Haile, Sarah R.; Peitzsch, Mirko; Schwarz, Esther I.; Sievi, Noriane A.; Kurth, Salome; Beuschlein, Felix; Kohler, Malcolm und Gaisl, Thomas (2019): Endocrine responses during CPAP withdrawal in obstructive sleep apnoea: data from two randomised controlled trials. In: Thorax, Vol. 74, No. 11: pp. 1102-1105

Abstract

The aim of this investigation was to elucidate the effect of CPAP withdrawal on neurometabolic and cardiometabolic markers in patients with obstructive sleep apnoea. We evaluated 70 patients (mean age 61 +/- 10 years, 82% men) treated with CPAP in two 2-week, parallel, randomised controlled trials. CPAP withdrawal resulted in elevated 3,4-dihydroxyphenylglycol, norepinephrine and cortisol after 2 weeks of CPAP withdrawal;however, no statistically significant changes of the renin-angiotensin-aldosterone system (RAAS) determinants were documented. In summary, CPAP withdrawal may be more prominently linked to short-term increases in sympathetic activation than hypothalamic-pituitary-adrenal axis or RAAS activation. ClinicalTrials.gov Identifier: NCT02493673 and NCT02050425.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0040-6376
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English