Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients

Keller, Andreas; Ludwig, Nicole; Fehlmann, Tobias; Kahraman, Mustafa; Backes, Christina; Kern, Fabian; Vogelmeier, Claus F.; Diener, Caroline; Fischer, Ulrike; Biertz, Frank; Herr, Christian; Joerres, Rudolf A.; Lenhof, Hans-Peter; Bals, Robert und Meese, Eckart (2019): Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients. In: Cells, Bd. 8, Nr. 10, 1162

Abstract

Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of COPD. Therefore, markers that predict individual survival of COPD patients are of great value. We analyzed baseline molecular profiles and collected 54 months of follow-up data of the cohort study "COPD and SYstemic consequences-COmorbidities NETwork" (COSYCONET). Genome-wide microRNA signatures from whole blood collected at time of the inclusion in the study were generated for 533 COPD patients including patients that deceased during the 54-month follow-up period (n = 53) and patients that survived this period (n = 480). We identified two blood-born microRNAs (miR-150-5p and miR-320b) that were highly predictive for survival of COPD patients. The expression change was then confirmed by RT-qPCR in 245 individuals. Ninety percent of patients with highest expression of miR-150-5p survived the 54-month period in contrast to only 50% of patients with lowest expression intensity. Moreover, the abundance of the oncogenic miR-150-5p in blood of COPD patients was predictive for the development of cancer. Thus, molecular profiles measured at the time of a COPD diagnosis have a high predictive power for the survival of patients.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch