Neues zur Therapie von neuroendokrinen Tumoren des gastroenteropankreatischen Systems

Auernhammer, Christoph Josef; Spitzweg, Christine; Böck, Stefan; Knoesel, Thomas und Bartenstein, Peter (2019): Neues zur Therapie von neuroendokrinen Tumoren des gastroenteropankreatischen Systems. In: Deutsche Medizinische Wochenschrift, Bd. 144, Nr. 20: S. 1390-1395

Abstract

Current guidelines have been published for the diagnosis and therapy of neuroendocrine neoplasms of the gastroenteropancreatic (GEP) system 1 . Systemic therapy of inoperable advanced neuroendocrine tumors includes biotherapy with somatostatin analogas, peptid receptor radionuclide therapy (PRRT) with 177Lutetium-DOTA-TATE, chemotherapy with steptozotocin/5-fluorouracil or capecitabine/temozolomide and molecular targeted therapy with everolimus or sunitinib 1 2 . For symptom control in patients with carcinoid syndrome biotherapy with somatostatin analogs, PRRT, loco-regional and local-ablative interventional procedures of liver metastases as well as the peripheral serotonin synthesis inhibitor telotristat Ethyl 1 2 3 4 are highly effective. Novel aspects and developments in the diagnosis and treatment of neuroendocrine tumors will be discussed in this review.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0012-0472
• Sprache: Deutsch