Resident memory CD8 T cells persist for years in human small intestine

Bartolome-Casado, Raquel; Landsverk, Ole J. B.; Chauhan, Sudhir Kumar; Richter, Lisa; Danh, Phung; Greiff, Victor; Risnes, Louise F.; Yao, Ying; Neumann, Ralf S.; Yaqub, Sheraz; Oyen, Ole; Horneland, Rune; Aandahl, Einar Martin; Paulsen, Vemund; Sollid, Ludvig M.; Qiao, Shuo-Wang; Baekkevold, Espen S. und Jahnsen, Frode L. (2019): Resident memory CD8 T cells persist for years in human small intestine. In: Journal of Experimental Medicine, Bd. 216, Nr. 10: S. 2412-2426

Abstract

Resident memory CD8 T (Trm) cells have been shown to provide effective protective responses in the small intestine (SI) in mice. A better understanding of the generation and persistence of SI CD8 Trm cells in humans may have implications for intestinal immune-mediated diseases and vaccine development. Analyzing normal and transplanted human SI, we demonstrated that the majority of SI CD8 T cells were bona fide CD8 Trm cells that survived for >1 yr in the graft. Intraepithelial and lamina propria CD8 Trm cells showed a high clonal overlap and a repertoire dominated by expanded clones, conserved both spatially in the intestine and over time. Functionally, lamina propria CD8 Trm cells were potent cytokine producers, exhibiting a polyfunctional (IFN-gamma(+) IL-2(+) TNF-alpha(+)) profile, and efficiently expressed cytotoxic mediators after stimulation. These results suggest that SI CD8 Trm cells could be relevant targets for future oral vaccines and therapeutic strategies for gut disorders.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0022-1007
• Sprache: Englisch