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Baquet, Moritz; Hoppmann, Petra; Grundmann, David; Schmidt, Wolfgang; Kufner, Sebastian; Theiss, Hans D.; Brunner, Stefan; Wiebe, Jens; Eickhoff, Madeleine; Jochheim, David; Byrne, Robert A.; Laugwitz, Karl-Ludwig; Schunkert, Heribert; Massberg, Steffen; Kastrati, Adnan and Mehilli, Julinda (2019): Sex and long-term outcomes after implantation of the Absorb bioresorbable vascular scaffold for treatment of coronary artery disease. In: Eurointervention, Vol. 15, No. 7: pp. 615-622

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Aims: Women and men suffering from coronary artery disease differ in their risk profiles. We sought to investigate the impact of sex on two-year outcomes after BVS implantation in routine clinical practice. Methods and results: Sex-based analysis of clinical outcomes was carried out by pooling the individual patient data of the ISAR-ABSORB and KUM-ABSORB registries performed in four high-volume tertiary centres in Munich. Of the total of 1,032 patients, 259 (25.1%) were women. The primary composite endpoint of death, target vessel myocardial infarction (TV-MI) and target lesion revascularisation (TLR) up to two years occurred in 13.2% of women and 17.9% of men (p=0.12). Compared to men, women experienced numerically lower rates of TLR and definite or probable BVS thrombosis - 7.5% vs 12.4% (p=0.051) and 1.2% and 2.7% (p=0.20), respectively. Independent predictors of increased risk for TLR were use of smaller size BVS (HR 1.28, 95% CI: 1.02-1.62), while being a woman was a protective factor (HR 0.59, 95% CI: 0.35-1.00). Conclusions: BVS used in a routine setting tend to perform better among women compared to men, which might be partially related to the lower complexity of their coronary artery disease.

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