Effect of Intraduodenal Bile and Na-Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Secretin, Pancreatic Polypeptide, and Gastrin in Man

Riepl, Rudolf L.; Lehnert, Peter; Scharl, A.; Hempen, I.; Fiedler, F.; Teufel, Johannes and Burhol, P. G. (1990): Effect of Intraduodenal Bile and Na-Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Secretin, Pancreatic Polypeptide, and Gastrin in Man. In: Scandinavian journal of gastroenterology, Vol. 25, No. 1: pp. 45-53

Abstract

The effect of intraduodenally administered cattle bile (CB) and Na-taurodeoxycholate (TDC) on basal pancreatic secretion and plasma levels of secretin, pancreatic polypeptide (PP), and gastrin were investigated on two separate days in 10 fasting volunteers. Doses of 2-6 g CB and 20&600 mg TDC were given intraduodenally at 65-min intervals. Volume, bicarbonate, lipase, trypsin, amylase, and bilirubin were measured in 10-min fractions of duodenal juice, and GI peptides determined by radioimmunoassay. CB and TDC enhanced significantly and dose-dependently volume, bicarbonate and enzyme secretion, and plasma secretin and PP levels. In contrast, plasma gastrin showed only a marginal increase. We conclude that the hydrokinetic effect of intraduodenal CB and TDC is at least partially mediated by secretin. Gastrin could be ruled out as a mediator of the ecbolic effect, whereas other GI peptides, primarily CCK, and/or neural mechanisms must be considered possible mediators. Both pathways may also play a role in the PP release.

• Item Type: Journal article
• Keywords: observed; Bile; bile salts; gastrin; GI peptides; Na-taurodeoxycholate; pancreatic polypeptide; pancreatic secretion; radioimmunoassay; secretin
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0036-5521